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Home/Large Joints and Extremities/SSRIs and Hip Replacement Risk With a Dose of Uncertainty
Large Joints and Extremities Premium

SSRIs and Hip Replacement Risk With a Dose of Uncertainty

By Robin YoungNovember 11, 2026 1 min read Premium comments

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SSRIs and Hip Replacement Risk With a Dose of Uncertainty
Source: Wikimedia Commons and Tom Varco
total hip arthroplastyperiprosthetic joint infectiondislocationrevisionSSRIperiprosthetic fractureclaims databasedose response

Preoperative medication lists rarely compete with radiographs for an orthopedic surgeon’s attention. A large new study suggests that one familiar entry deserves a closer look: the selective serotonin reuptake inhibitor, or SSRI.

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