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Home/Large Joints and Extremities/Is Hyaluronic Acid Just Expensive Salt Water? A Level I Trial Reignites THAT Debate
Large Joints and Extremities Premium

Is Hyaluronic Acid Just Expensive Salt Water? A Level I Trial Reignites THAT Debate

July 20, 2026 1 min read Premium comments

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Is Hyaluronic Acid Just Expensive Salt Water? A Level I Trial Reignites THAT Debate
Courtesy of Wikimedia Commons
knee osteoarthritisrandomized controlled trialhyaluronic acidintra-articular injectionmolecular weightviscosupplementation

A new Level I randomized, double-blind, placebo-controlled trial published in JBJS Open Access compared two of today's most advanced single-injection cross-linked hyaluronic acid formulations against perhaps the simplest comparator imaginable: sterile saline.

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