Can Vitamin B12 Prevent One of Orthopedics' Most Feared Complications?

July 20, 2026 1 min read Premium comments

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randomized controlled trialmecobalamincomplex regional pain syndromeCRPS-1foot and ankle surgeryprevention

Complex Regional Pain Syndrome (CRPS) has long been one of orthopedics' most frustrating postoperative complications. It is unpredictable, difficult to treat, and capable of turning technically excellent surgery into a disappointing outcome for both surgeon and patient.

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