Edwin A. Hissa II, M.D., an orthopedic surgeon at Holzer Medical Center in Jackson, Ohio, passed away on Wednesday, April 17, 2024, at the age of 70.
Holzer Medical Center Orthopedic Surgeon Edwin Hissa II Dies at 70

Hissa practiced orthopedic surgery for 32 years before his recent retirement. He specialized in joint replacement, arthroscopy, sports medicine, adult reconstruction, and trauma. He earned his medical degree from the University of Cincinnati and did his surgical internship and orthopedic residency at The Cleveland Clinic in Cleveland, Ohio.
Hissa served patients at Cleveland Clinic’s Hillcrest Hospital in Mayfield Heights, Ohio, and at Lake Hospital System in Painesville, Ohio, before joining Holzer in 2008. He also ran his own practice.
He returned to Holzer in 2012 and served patients at the Gallipolis and Jackson locations. He was a member of the American Academy of Orthopaedic Surgeons, the American Medical Association, Ohio Medical Association, and the Academy of Medicine in Cleveland.
Hissa was born on October 20, 1953, in Cleveland, Ohio. He spent his formative years in Burton, Ohio.
He most recently lived in Jackson and attended St. Helen Catholic Church in Newbury and Holy Trinity Catholic Church in Jackson.
Hissa is survived by his wife, Evelyn Woolman Hissa, his children Erin Cunningham, Edwin Hissa, Julia Hissa and his stepchildren, Thomas Enerva, Samuel Enerva and Joseph Enerva. He also leaves behind his sisters, Ann Humphrey and Alisa Humphrey, his brothers Michael Hissa and Mathew Hissa and his five grandchildren, nieces, and nephews. He was preceded in death by his parents Edwin and Joan Hissa and his brother Mark Hissa.

Discussion
This is a fascinating development. In my practice we've seen similar outcomes with the revised protocol. The key differentiator seems to be patient selection criteria. Has anyone else noticed the correlation with BMI thresholds?
Great point. I'd push back slightly on the conclusion, the sample size in the cited study is too small to draw population-level inferences. That said, the directional signal is compelling and worth a larger RCT.
We implemented a similar approach last year. Early results are promising but we're still gathering 12-month follow-up data. Happy to share our protocol if anyone is interested.
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