Phoenix, Arizona-based Creative Medical Technology Holdings, Inc., a commercial stage biotechnology company which is commercializing a line of stem cell-based products, raised $16 million in an initial public offering of its stock.
Stem Cell Company Raises $16M in IPO
According to Creative Medical, it is “focused on a regenerative approach to immunotherapy, urology, neurology, and orthopedics.” Its product pipeline includes the following products: StemSpine®, CaverStem®, FemCelz®, ImmCelz®, and OvaStem®.
StemSpine is a “regenerative stem cell procedure for treatment of degenerative disc disease.” CaverStem is a “regenerative stem cell procedure for treatment of erectile dysfunction in men.” FemCelz is a “regenerative stem cell procedure for treatment of female sexual dysfunction.” ImmCelz is “amniotic fluid derived stem cells for treatment of stroke.” OvaStem is a “stem cell treatment for premature ovarian failure.”
With this sale of 3,875,000 shares of Creative Medical stock, the company raised $16 million and will trade on Nasdaq under the ticker symbol “CELZ.”
The sole underwriter of the issue was Newport Beach, California-based Roth Capital Partners, a small privately held investment banking company. The offering was a combination of “common stock and accompanying warrants to purchase up to 3,875,000 shares of common stock at a combined public offering price of $4.13.” Additionally, the warrants had “a per share exercise price of $4.13, are exercisable immediately, and expire five years from the date of issuance.”
Creative Medical Technology Holdings also announced that it “has granted to the underwriters of the offering a 45-day option to purchase up to 581,250 additional shares and/or additional warrants to purchase up to 581,250 shares of common stock to cover over-allotments, if any.”

Discussion
This is a fascinating development. In my practice we've seen similar outcomes with the revised protocol. The key differentiator seems to be patient selection criteria. Has anyone else noticed the correlation with BMI thresholds?
Great point. I'd push back slightly on the conclusion, the sample size in the cited study is too small to draw population-level inferences. That said, the directional signal is compelling and worth a larger RCT.
We implemented a similar approach last year. Early results are promising but we're still gathering 12-month follow-up data. Happy to share our protocol if anyone is interested.
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