NovaBone Products, LLC, a biomaterials company located in Jacksonville, Florida, is expanding its portfolio of bioactive bone void fills with two new products based on the combination of bioactive glass and bovine collagen. The products are called MacroFORM Packable Graft and MacroFORM Composite.
NovaBone Ups the BioGlass Ante With Two New Products
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The first combines 85% bioactive ingredient with collagen in a mixing cup while the second combines 90% bioactive ingredient with collagen in a preformed strip. Company officials claim that MacroFORM’s highly bioactive collagen scaffold is engineered to have an open porous structure to enhance the absorption of bone marrow aspirate and facilitate bone growth. Both products can be manipulated into a putty format after mixing.
“Since its inception, our company has developed numerous formulations and delivery systems that accelerated bone growth, ” said NovaBone’s President Arthur Wotiz. “We are especially proud of this collagen-based product and will continue to pioneer collagen grafting options, ” he added.
In 2005 the Food and Drug Administration authorized use of the term “osteostimulation, ” to describe how bioactive products signal genetic pathways to accelerate the regeneration of bone. Officials of NovaBone claim that their product was the first bioactive synthetic bone graft product to be offered to the orthopedic community.
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This is a fascinating development. In my practice we've seen similar outcomes with the revised protocol. The key differentiator seems to be patient selection criteria. Has anyone else noticed the correlation with BMI thresholds?
Great point. I'd push back slightly on the conclusion, the sample size in the cited study is too small to draw population-level inferences. That said, the directional signal is compelling and worth a larger RCT.
We implemented a similar approach last year. Early results are promising but we're still gathering 12-month follow-up data. Happy to share our protocol if anyone is interested.
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