The privately held regenerative medicine firm Histogenics Corp. has hired Peter Greenleaf, former president of AstraZeneca, to be its new CEO, according to Julie M. Donnelly, writing for the Boston Business Journal. He succeeds Patrick O’Donnell who became CEO when Histogenics merged with Prochon in 2011.
Histogenics Names Peter Greenleaf CEO

Histogenics’ lead product is NeoCart, which uses a patient’s own knee cartilage, harvested during a diagnostic arthroscopy procedure, to regrow cartilage, which is then put back into the patient using a small incision. NeoCart is currently undergoing a Phase 3 trial.
Greenleaf previously served as president of MedImmune, AstraZeneca’s biologics business, and MedImmune Ventures, where he oversaw more than $300 million in investments in early stage portfolio companies. Prior to MedImmune, Greenleaf held a variety of positions at Centocor, most recently as the Vice President of the U.S. gastroenterology commercial group.
“Peter’s expertise in growing smaller biotech companies into industry leaders will be critical as we work to move NeoCart through pivotal trials and ultimately toward launch and commercialization, ” said Garheng Kong, Histogenics chairman and Sofinnova Ventures general partner. “While NeoCart will be the main focus in the near term, Peter will also help facilitate our vision for building out the company’s platform technology and the future growth plans for the organization.”

Discussion
This is a fascinating development. In my practice we've seen similar outcomes with the revised protocol. The key differentiator seems to be patient selection criteria. Has anyone else noticed the correlation with BMI thresholds?
Great point. I'd push back slightly on the conclusion, the sample size in the cited study is too small to draw population-level inferences. That said, the directional signal is compelling and worth a larger RCT.
We implemented a similar approach last year. Early results are promising but we're still gathering 12-month follow-up data. Happy to share our protocol if anyone is interested.
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