Mix bone stem cells and a new plastic and voila…we have a novel artificial bone. The degradable rigid plastic is combined with the stem cells, inserted into broken bones where it then encourages real bone to re-grow. This new discovery is the result of a seven-year partnership between the University of Southampton and the University of Edinburgh.
New Artificial Bone Created
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Researchers have developed the material with a honeycomb scaffold structure that allows blood to flow through it, enabling stem cells from the patient’s bone marrow to attach to the material and grow new bone. Over time, the plastic—which is a mixture of three types of plastics—slowly degrades as the implant is replaced by newly grown bone. They used a pioneering technique to blend and test hundreds of combinations of plastics, to identify a blend that was robust, lightweight, and able to support bone stem cells. Successful results have been shown in the lab and in animal testing with the focus now moving towards human clinical evaluation. The study, published in the journal Advanced Functional Materials, was funded by the Biotechnology and Biological Sciences Research Council.
In the February 8, 2013 news release, Richard Oreffo, professor of Musculoskeletal Science at the University of Southampton, commented, “Fractures and bone loss due to trauma or disease are a significant clinical and socioeconomic problem. This collaboration between chemistry and medicine has identified unique candidate materials that support human bone stem cell growth and allow bone formation. Our collaborative strategy offers significant therapeutic implications.”
Professor Mark Bradley of the University of Edinburgh’s School of Chemistry, added, “We were able to make and look at a hundreds of candidate materials and rapidly whittle these down to one which is strong enough to replace bone and is also a suitable surface upon which to grow new bone. We are confident that this material could soon be helping to improve the quality of life for patients with severe bone injuries, and will help maintain the health of an ageing population.”
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This is a fascinating development. In my practice we've seen similar outcomes with the revised protocol. The key differentiator seems to be patient selection criteria. Has anyone else noticed the correlation with BMI thresholds?
Great point. I'd push back slightly on the conclusion, the sample size in the cited study is too small to draw population-level inferences. That said, the directional signal is compelling and worth a larger RCT.
We implemented a similar approach last year. Early results are promising but we're still gathering 12-month follow-up data. Happy to share our protocol if anyone is interested.
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